Group

This group investigates the mechanisms of resistance of bacteria to antibiotics, and new ways to circumvent them. Group found that the mouth carries a very high

proportion of bacteria resistant to several antibiotics. With concerns >> << was their opinion that this high level of antimicrobial resistant organisms

present in humans (including children) who

-not recently (within 3 months) was obtained drugs . In addition, resistant species can persist in the mouth for a long period >> << time (more than 18 months) in the absence of antimicrobial products.

As well as identifying the genes responsible for

antimicrobial resistance in bacteria of the mouth, they have been identified and characterized a novel

antimicrobial resistance genes. In addition, the group

showed that the genes that encode resistance to antimicrobial agents may

transfer between organisms (even those that are distantly related) and >> << in vitro and in vivo. The team also conducted extensive research

in exile in bacteria of the oral cavity between the

resistance and resistance to mercury. Just as

to show that healthy individuals harbor high oral >> << bacteria resistant to mercury, antimicrobial agents, they

characterize genes that encode mercury resistance and is

showed that dental restorations mixture can force >> << colonization by bacteria (eg, Streptococcus oral) that can be >> << systemic relevance in the immune host. Group

first separate profile of resistance to antimicrobial drugs in the endodontic microflora >> << and determine which resistance genes can be transferred between

bacterial isolates from root canals. Group

In addition, significant progress in the development of Novi

antimicrobial technology. One particular emphasis was placed on photodynamic therapy >> << funded by large research council (SIBBN, EPSRC, MRC),

Charles Wilson Foundation and Industry (Ondine Pharma and

Dentofex). Group developed a new photosensitizers that can selectively affect

to kill certain microorganisms, including

meticillin resistant Staphylococcus aureus

(MRSA) and important periodontopathogen gingivalis Porphyromonas. received a further development of relations with industry (Ondine Biopharma) for treatment

system that is used in the clinic, was launched in

Pacific Dental Conference in Vancouver, Canada in 2006 and now

used by 15% of Canadian dentists. Ondine Biopharma recently received

sign of CE, which will allow them to sell Periowave in Europe. Sustainable quality of this theme is reflected burning

EPSRC funding and Ondine Pharma, expanding the use of

light-activated antimicrobial coating new photosensitizers

and methods for selective effects on bacteria. Another important topic is the study of natural products

with antibacterial, anti-inflammatory or anti-adhesive

compounds for the prevention and / or treatment of caries and periodontitis

. International consortium led by UCL-EDI group

recently was awarded

(2. 2 million euros) to determine the characteristics and evaluation of compounds

present in foods and beverages that may be useful for prevention

and / or treatment of oral diseases . They plan to include such compounds

to means of oral hygiene and the development of functional food

, contain them. Diaz Torres ML, Villedieu, Hunt N, R MakNab, Spratt DA, Allan E, P Mullany and M. Wilson 2006. Determination of antibiotic resistance potential of the indigenous oral mikrobioty human use Metahenomnyy approach. Decraene V, J Pratten and Wilson, M. 2006. Cellulose acetate containing toluidine blue and rose Bengal is an effective antimicrobial coating when exposed to white light. Rossi-Fedele G, Scott W, Spratt D, K and Gulabivala Roberts AP. In 2006. Incidence and behavior of strattera online Tn916 like elements in tetracycline-resistant bacteria isolated from root canals. Ready D, J Pratten Roberts AP, Bedi R, P Mullany and M. Wilson 2006. Potential role of Veillonella SPP. as a reservoir for the transfer of tetracycline resistance in the oral cavity. .